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The Total Immunoglobulin E (IgE) test measures the total level of IgE — the antibody class central to allergic and anti-parasit...
Also known as: Total IgE Test · Serum IgE Test · Total Immunoglobulin E Test · Allergy Blood Test · IgE Level Test
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*Inclusive of home collection charges
The Total Immunoglobulin E (IgE) test measures the total level of IgE — the antibody class central to allergic and anti-parasitic immune responses — in the blood. IgE is produced by B cells in response to allergens (pollen, dust mites, food, pet dander) and parasitic antigens. Elevated total IgE is associated with allergic conditions (asthma, allergic rhinitis, atopic eczema, food allergy) and parasitic infections. The test provides an overall measure of allergic immune activity — when elevated, it is followed by specific IgE testing (RAST/ImmunoCAP) to identify the exact allergen(s) responsible. No fasting required.
Key benefits of this package include:
What Does the Immunoglobulin E (IgE) — Total Test Measure?
| Level / Result | Possible Interpretation |
|---|---|
| < 100 IU/mL (Normal) | Normal total IgE — allergic sensitisation unlikely as a cause of symptoms (though not excluded; specific IgE may still be elevated) |
| 100–500 IU/mL (Elevated) | Mild-moderate elevation — allergic sensitisation likely; specific IgE testing recommended to identify allergen(s) |
| 500–1,000 IU/mL (High) | Significant elevation — moderate-severe atopic disease or parasitic infection; further investigation required |
| > 1,000 IU/mL (Very high) | Markedly elevated — severe atopic disease, hyper-IgE syndrome, heavy parasitic infection (helminths); specialist evaluation |
| > 5,000 IU/mL (Extreme elevation) | Hyper-IgE syndrome (Job's syndrome) — rare primary immunodeficiency; paediatric immunology evaluation |
Important Note: Total IgE elevation is not specific to any single condition — it must be interpreted alongside clinical history, symptom pattern, AEC, and specific IgE results. Importantly, a normal total IgE does not exclude specific IgE sensitisation — some patients have elevated specific IgE to particular allergens despite normal total IgE. For allergen identification, specific IgE (ImmunoCAP) testing is required regardless of total IgE level. All results must be reviewed by a physician or allergist.
Total IgE and Anti-IgE Therapy (Omalizumab): Omalizumab is a monoclonal antibody therapy for severe allergic asthma and chronic urticaria — it binds and neutralises free IgE, preventing mast cell and basophil activation. Baseline total IgE is mandatory before initiating omalizumab — both to confirm IgE-mediated disease (requirement for treatment eligibility) and to calculate the correct dose (which is based on baseline IgE level and body weight). The treatment target is not to reduce total IgE (which often paradoxically rises on omalizumab as bound IgE accumulates) but to reduce free IgE below the threshold that activates mast cells.
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